LifeLines Cohort Study & Biobank
Overall aim of the LifeLines study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait. The primary objectives are to establish which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime, and how are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual. Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiology, renal diseases, pulmonary and musculoskeletal diseases, and psychopathology. Secondary objectives: Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases and their risk factors in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.
- Start Year
- 2007
- Supplementary Information
- <p>Funding Agencies: Governement, 3 northern provinces of The Netherlands (80%), University Med Center Groningen/ University of Groningen (15%), The Netherlands Organization for Scientific Research (NWO) (5%), Dutch Diabetes Research Foundation and Dutch Kidney Foundation</p>
Visit LifeLines
| Investigators | Contacts |
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Design
- Study design
- Cohort
- Follow Up
- <p><span>The participants are followed for at least thirty years and are invited every five years for a medical examination. In the years in-between (every 1.5 years) the participants recieve follow-up questionnaires.</span></p>
Marker Paper
Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74.
PUBMED 18075776
Recruitment
- Sources of Recruitment
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- Individuals
- Families
Number of participants
- Number of participants
- 165,000
- Number of participants with biosamples
- 165,000
- Supplementary Information
- <p><span>45 000 probands who invite their family members (30000 partners, 55000 parents (including in laws) and 35000 children).</span></p>
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |
Timeline
LifeLines population
The study population consists of a representative sample of the population of the northern provinces of the Netherlands, covering three generations. The LifeLines project will include 165.000 participants: anticipated to consist of approximately45.000 probands, 30.000 partners, 55.000 parents-(in law) and 35.000 children. Based on the age of the participant, he or she is included in the children’s cohort (0-18 years), the adult cohort (18-65 years) or the elderly cohort (>65 years).
Selection Criteria
- Newborns
- Twins
- Countries
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- Netherlands
- Territory
- <p><span>Three Northern provinces: Groningen, Friesland and Drenthe</span></p>
- Health Status
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- Severe psychiatric or physical illness are excluded
Recruitment
- Sources of recruitment
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- General population
- General Population
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- Volunteer enrolment
Number of participants
- Number of participants
- 165,000
- Number of participants with biosamples
- 165,000
- Supplementary Information
- <p><span>155000 participants as of 19 Sept 2013</span></p>
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 |
Preparation phase/pilot
|
2004-01 | 2006-12 | |
| 0 |
Baseline visit
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Baseline visit of participants. Questionnaires: Demographics, Family composition, Work and educational level, Health, Birth and development, Lifestyle ... |
2007-01 | 2013-12 |
| 0 |
Follow-up questionnaire 1
|
Follow-up of participant at approx 2 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care ... |
2010-01 | 2014-12 |
| 0 |
Follow-up questionnaire 2
|
Follow-up of participants at 3 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ... |
2012-01 | 2015-12 |
| 0 |
Follow-up questionnaire 3
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Follow-up of participants at approx. 5 years after Baseline visit. Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ... |
2014-01 | 2017-12 |
| 0 |
Follow-up visit 1
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Follow-up visit of participants at 5 years after Baseline visit. Questionnaires: Demographics, Family composition, Work and educational ... |
2014-01 | 2017-12 |