Individual Study / LifeLines

LifeLines Cohort Study & Biobank

LifeLines Cohort Study & Biobank

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Overall aim of the LifeLines study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait. The primary objectives are to establish which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime, and how are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual. Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiology, renal diseases, pulmonary and musculoskeletal diseases, and psychopathology. Secondary objectives: Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases and their risk factors in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.

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Investigators Contacts
  • Dr. Ronald Stolk
    University Medical Center Groningen
  • Ymke van der Geld
    University Medical Center Groningen
  • Dr. Salome Scholtens
    University Medical Center Groningen
  • Dr. Ronald Stolk
    University Medical Center Groningen

Conception

Study design
Cohort
Start Year
2007
Follow Up

The participants are followed for at least thirty years and are invited every five years for a medical examination. In the years in-between (every 1.5 years) the participants recieve follow-up questionnaires.

Supplementary Information

Funding Agencies: Governement, 3 northern provinces of The Netherlands (80%), University Med Center Groningen/ University of Groningen (15%), The Netherlands Organization for Scientific Research (NWO) (5%), Dutch Diabetes Research Foundation and Dutch Kidney Foundation

Marker Paper

Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74.

PUBMED 18075776

Recruitment

Sources of Recruitment
  • Individuals
  • Families

Number of participants

Number of participants
165,000
Number of participants with biosamples
165,000
Supplementary Information

45 000 probands who invite their family members (30000 partners, 55000 parents (including in laws) and 35000 children).

Access

Availability of data and biosamples

Data
Biosamples
Other

Timeline

Population

The study population consists of a representative sample of the population of the northern provinces of the Netherlands, covering three generations. The LifeLines project will include 165.000 participants: anticipated to consist of approximately45.000 probands, 30.000 partners, 55.000 parents-(in law) and 35.000 children. Based on the age of the participant, he or she is included in the children’s cohort (0-18 years), the adult cohort (18-65 years) or the elderly cohort (>65 years).

Selection Criteria
Newborns
Twins
Countries
  • Netherlands
Territory

Three Northern provinces: Groningen, Friesland and Drenthe

Health Status
  • Severe psychiatric or physical illness are excluded

Recruitment

Sources of recruitment
  • General population
General Population
  • Volunteer enrolment

Number of participants

Number of participants
165,000
Number of participants with biosamples
165,000
Supplementary Information

155000 participants as of 19 Sept 2013

Data Collection Events
# Name Description Start End
0 Preparation phase/pilot 2004-01 2006-12
0 Baseline visit

Baseline visit of participants.

Questionnaires: Demographics, Family composition, Work and educational level, Health, Birth and development, Lifestyle ...

2007-01 2013-12
0 Follow-up questionnaire 1

Follow-up of participant at approx 2 years after Baseline visit. 

Change of address / change in family members, Incidence of diseases / visits to health care ...

2010-01 2014-12
0 Follow-up questionnaire 2

Follow-up of participants at 3 years after Baseline visit.

Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ...

2012-01 2015-12
0 Follow-up questionnaire 3

Follow-up of participants at approx. 5 years after Baseline visit.

Change of address / change in family members, Incidence of diseases / visits to health care providers, Medication ...

2014-01 2017-12
0 Follow-up visit 1

Follow-up visit of participants at 5 years after Baseline visit.

Questionnaires: Demographics, Family composition, Work and educational ...

2014-01 2017-12