Individual Study / FRéLE

FRéLE: Fragilité, une étude longitudinale de ses expressions [Frailty, a longitudinal study of its expressions]

FRéLE: Fragilité, une étude longitudinale de ses expressions [Frailty, a longitudinal study of its expressions]

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The first objective of this research project will be to investigate the extent to which psychosocial and biological markers of frailty can be added to the five components of the Fried’s model of the frailty syndrome. The second objective of the project is to identify homogeneous subgroups of elderly persons, or profiles of frailty, that demonstrate a specific pattern of associations among a subset of the components of frailty and/or potential biological and psychosocial markers.

Objective 1a - The starting point for the first objective is a definition of frailty as a clinical syndrome based on the presence of the five Fried’s physiological components: unintentional weight loss, low muscle strength, poor physical performance, low physical activity, and feeling of exhaustion. The extent to which these five measures can be considered as components of a frailty syndrome will be examined.

Objective 1b – Components such as cognition and mood, and candidate psychosocial components will be added to the five Fried’s components and their inclusion in the frailty syndrome examined.

Objective 1c - Relationships between components of frailty can vary at different points in time. Trajectories of frailty will be identified using the biological, functional and psychosocial markers of profiles of frailty selected in the Objective 1a and 1b studies.

Objective 2a - In the study of predictors of frailty, the primary dependent variables are frailty trajectories. The primary predictors of frailty trajectories considered in this study are socio-economic status (SES), structural aspects of social network and positive and negative social support, self-efficacy and gender. Smoking, sleep patterns, lifelong physical exercise, and risk of energy and nutritional deficiencies will also be assessed.

Objective 2b - The consequences of frailty in terms of the Verbrugge & Jette model of disabilities will be examined. As in the Lebel et al. modeling of the frailty process, frailty will be considered as a modifier of pathways from pathology through functional limitations, disabilities and finally to death. These consequences are those usually considered in the examination of the validity of the components of frailty syndrome.

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Investigators Contacts
  • Dr. José A. Morais
    McGill University Health Centre
  • Dr. François Béland
    Université de Montréal
  • Dr. Christina Wolfson
    McGill University
  • Dr. Marie-Jeanne Kergoat
    Institut universitaire de gériatrie de Montréal
  • Dr. Hélène Payette
    Research Center on Aging, Health and Social Services Centre — University Institute of Geriatrics of Sherbrooke (CSSS-IUGS)
  • Dr. René Verreault
    Hôpital du Saint-Sacrement
  • Dr. Louise Demers
    Institut universitaire de gériatrie de Montréal
  • Dr. Bryna Shatenstein
    Institut universitaire de gériatrie de Montréal Research Centre
  • Dr. Réjean Hébert
    Institut universitaire de gériatrie de Sherbrooke
  • Dr. Tamàs Fülöp
    Université de Sherbrooke
  • Dr. Howard Bergman
    Université McGil
  • Dr. Maria-Victoria Zunzunegui
    Université de Montréal Public Health Research Institute (IRSPUM)
  • Dr. Johanne Desrosiers
    Université de Sherbrooke
  • Dr. Pierrette Gaudreau
    University of Montreal Hospital Research Centre
  • Claude Galand
    Jewish General Hospital

Conception

Study design
Cohort
Start Year
2010
End Year
2013
Follow Up

Three year longitudinal study (T0, T1, and T2), with face-to face measurement at a 1-year interval, and six-month phone interview (T0.5, T1.5)

Supplementary Information

Béland F, Michel H, La fragilité des personnes âgées : définitions, controverses et perspectives d’action, Rennes, Presses de l’EHESP, 2013.

Béland F, Michel H, Explorer la fragilité : d’un syndrome gériatrique à une notion polymorphe? Pp 7-30 in Béland F, Michel H, La fragilité des personnes âgées : définitions, controverses et perspectives d’action, Rennes, Presses de l’EHESP, 2013.

Galand C Béland F, Fletcher J, FRéLE : une étude québécois sur la fragilité, pp177-204, in Béland F, Michel H, La fragilité des personnes âgées : définitions, controverses et perspectives d’action, Rennes, Presses de l’EHESP, 2013.

Marker Paper

Galand, C., Béland, F., & Fletcher, J. (2012). FRÉLE: Fragilité, une étude longitudinale de ses expressions. Rapport descriptif sur les données obtenues durant les entrevues face-à-face au temps « TO ». Publications Solidage.

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
1,643
Number of participants with biosamples

Access

Availability of data and biosamples

Data
Biosamples
Other

Timeline

Population

Older adults aged 65 years and older

Selection Criteria
Minimum age
65
Newborns
Twins
Countries
  • Canada
Territory

Montréal, Sherbrooke, Victioriaville

Other criteria

Living at home or apartment

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
1,643
Number of participants with biosamples
Data Collection Events
# Name Description Start End
0 T0

Face-to-face interviews carried out by health professionals in participant’s dwelling.

2010-02 2010-08
0 T1

Face-to-face interviews carried out by health professionals in participant’s dwelling.

2011-02 2011-08
0 T2

Face-to-face interviews carried out by health professionals in participant’s dwelling.

2012-02 2012-08